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A Paramecium cell has as many types of membrane interactions as mammalian cells, as established with monoclonal antibodies by R. Allen and A. Fok. Since then, we have identified key players, such as SNARE proteins, Ca2+‐regulating proteins, including Ca2+‐channels, Ca2+‐pumps, Ca2+‐binding proteins of different affinity, etc., at the molecular level, probed their function and localized them at the...